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Image Search Results
Journal: The Journal of Immunology Author Choice
Article Title: Repositioning the Early Pathology of Type 1 Diabetes to the Extraislet Vasculature
doi: 10.4049/jimmunol.2300769
Figure Lengend Snippet: Anatomy of lymphatics in normal and diseased human pancreatic islets. (A) No LYVE-1 islet-associated staining was detected in tissue from normal donors. (B and C) Lymphatics were present in islets from type 1 diabetes donors. (D) Similar to the NOD mouse lesion, CD4 T cells accumulated on the outside of the islet and were associated to lymphatic vessels. (E) Based on the intensity of the insulin stain, the successive steps of the human lesion are shown in a single specimen in which, from left to right, normal islets, lymphatic-associated islets, and nearly and fully destroyed islets were found. Zoomed-in regions where LYVE-1 staining was present showed the intimate relationship between lymphatics and the outside of the islet. Scale bars, 50 µm.
Article Snippet: Normal human and
Techniques: Staining